Buchet JP, Analytical Techniques for Heavy Metals in Biological Fluids, 75 (1981). Lenz K., Hruby K., Druml W., Eder A., Gaszner A., Kleinberger G., Pichler M., Weiser M., 2,3-Dimercaptosuccinic acid in human arsenic poisoning, 10.1007/bf00368684. Mückter Harald, Lieb Bernhard, Reich Franz-Xaver, Hunder Göran, Walther Udo, Fichtl Burckhard, Are we ready to replace dimercaprol (BAL) as an arsenic antidote?, 10.1177/096032719701600807. Aposhian H.Vasken, Maiorino Richard M., Gonzalez-Ramirez Diego, Zuniga-Charles Miguel, Xu Zhaofa, Hurlbut Katherine M., Junco-Munoz Pablo, Dart Richard C., Aposhian Mary.M., Mobilization of heavy metals by newer, therapeutically useful chelating agents, 10.1016/0300-483x(95)02965-b. MD/MINT - Département de médecine interneĪdult Antidotes - administration & dosage - therapeutic use Arsenic - urine Arsenic Poisoning - drug therapy - psychology - therapy Fatal Outcome Hemodynamics - drug effects - physiology Homicide Humans Injections, Intravenous Kidney Failure, Acute - chemically induced - therapy Male Peritoneal Dialysis Succimer - administration & dosage - therapeutic use Marcel Dekker ((United States) New York, NY) The patient died on day 26 from the consequences of multiple organ failure, with subarachnoid hemorrhage and generalized infection caused by Aspergillus fumigatus.Īrticle de périodique (Journal article) – Article de recherche These amounts appeared negligible with regard to the probable ingested dose. It was calculated that over an 11-day period 14.5 mg arsenic were eliminated by the urine, 26.7 mg by hemodialysis, 17.8 mg by peritoneal dialysis, and 7.8 mg by continuous venovenous hemofiltration. 
Continuous venovenous hemofiltration combined with hemodialysis, and peritoneal dialysis were proposed to enhance arsenic elimination. Intravenous DMSA infusion was well tolerated and resulted in an increase in arsenic blood concentration immediately after the infusion. DMSA was administered by intravenous (20 mg/kg/d for five days, then 10 mg/kg/d for six days) and intraperitoneal route. Dimercaprol (BAL) and dimercaptosuccinic acid (DMSA or succimer) were used simultaneously as arsenic chelating agents for two days, and thereafter DMSA was used alone. In addition to supportive therapy, extrarenal elimination techniques and chelating agents were used. The patient developed severe manifestations of toxic hepatitis and pancreatitis, and thereafter neurological disorders, respiratory distress, acute renal failure, and cardiovascular disturbances. Arsenic poisoning was diagnosed in a 26-year-old man who had been criminally intoxicated over the last two weeks preceding admission by the surreptitious oral administration of probably 10 g of arsenic trioxide (As2O3).
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